AtheroNova Inc. (AHRO), a biotech company focused on the research and development of compounds to safely regress atherosclerotic plaque and improve lipid profiles in humans, today announced that Erik SG Stroes, MD, Chair and Professor at the Department of Vascular Medicine at the Academic Medical Center (AMC), Amsterdam has joined the Company as a member of the Clinical Advisory Board.
“We are pleased to announce that Dr. Stroes has joined AtheroNova in this very important clinical advisory role as we continue to expand our scientific and medical teams as we transition to a clinical stage company,” stated Thomas W. Gardner, CEO of AtheroNova. “Dr. Stroes’ leadership in the area of lipidology has been an integral part of many atherogenesis studies. We feel that adding Dr. Stroes to the AtheroNova team is significant in its impact on the knowledge he will contribute to our clinical efforts.”
“Professor Stroes is world renowned for his cutting edge clinical care of cardiovascular patients and for his pioneering clinical research activities that have contributed to a very significant reduction in the ravages of cardiovascular disease in this decade,” commented Mark K. Wedel, M.D., Chief Medical Officer of AtheroNova. “We are honored that Erik will be bringing his talents and leadership to AtheroNova’s efforts to further improve the plight of cardiovascular patients.”
“I was initially attracted to AtheroNova by the team that they are building, including my colleagues Dr. John Kastelein and Dr. Steve Nicholls,” remarked Dr. Stroes. “AtheroNova’s science, though early-stage, has a chance to become an important part of the treatment of cardiovascular disease. I am looking forward to building on the research success of AHRO-001 and the opportunity to evaluate the drug in clinical trials.”
For over two decades, Dr. Stroes has focused on the role of the vessel wall in atherogenesis development. In the late nineties, he studied modulation of endothelial nitric oxide synthase (co-factor suppletion, gene therapy) as a major topic for research, leading to the first demonstration of the relevance of nitric oxide synthase uncoupling in humans with dyslipidemia.
Since his transition to the AMC, Dr. Stroes has focused on lipid disorders in relation to atherogenesis. He has participated in numerous lipid lowering trials using surrogate markers such as intima media thickness (ENHANCE study) and flow mediated dilation. More recently, he has observed that 3T-MRI has been added as surrogate marker for vascular disease progression. In addition, his observations on novel gene defects contributing to lipid disorders (HDLc, hypertriglyceridemia) have been pursued by collecting autosomal dominant families with these disorders.
Additionally, Dr. Stroes has been involved in the development of novel therapeutic moieties for dyslipidemia, such as Lipoprotein lipase gene therapy, apoB antisense, reconstituted HDL-infusion and other novel compounds. To date, he has published more than 195 papers in peer reviewed journals.
AtheroNova Inc. is a biotechnology company focused on the discovery, research, development and licensing of novel compounds to safely reduce or regress atherosclerotic plaque deposits and improve lipid profiles in humans. In addition to its lead compound AHRO-001, AtheroNova plans to develop multiple applications for its patented and patents-pending therapies in market sectors that include: Cardiovascular Disease, Stroke, Peripheral Artery Disease, Dementia and Alzheimer’s and Erectile Dysfunction, all of which have been linked to atherosclerosis. Atherosclerosis and its related pharmaceutical expenses for these indications cost consumers more than $41 billion annually in the United States alone. For more information, please visit www.AtheroNova.com.
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